多发性肌炎发病机制中的血管因素研究

A study of vascular factor in the pathogenesis of polymyositis

目的 研究多发性肌炎中细胞间黏附分子 1(ICAM 1)、IL 1α在微血管的表达情况,探讨血管因素在多发性肌炎中的作用。方法 收集 10例多发性肌炎患者和 6例非炎性肌病,采用图像分析法计算CD34、ICAM 1、IL 1α阳性微血管面积与面密度,进行定量分析和比较。结果 多发性肌炎患者肌组织中微血管面密度较非炎性肌病组明显减少 (P=0 009 );微血管内皮ICAM 1、IL 1α的表达强度较对照组增强。结论 多发性肌炎患者肌组织微循环功能受损,提示血管因素可能参与了多发性肌炎的发病。

Objective To study ICAM-1, IL-1α expression in capillaries and to explore whether capillaries play a role in the pathogenesis of polymyositis.Methods Ten cases of patients with polymyositis and 6 patients with other myopathies were collected. CD 34, ICAM-1 and IL-1α were selected for a quantitative measurement using an image analysis system, and results were presented as the percent of positive staining in the tissue area.Results We found that the percent of capillaries in tissues from polymyositis was significantly less than that from controls(P=0.009). ICAM-1 and IL-1α expression in endothelial cells of capillaries were stronger in polymyositis patients.Conclusion Our findings indicated that changes of capillaries might participate in the pathogenesis of polymyositis.