HPLC法测定犬体内罗格列酮药物动力学参数

Determination of Pharmacological Parameters for Rosiglitazone in Dogs by HPLC

目的-研究马来酸罗格列酮在犬体内的药动学特点。方法-以乙腈固相提取, HPLC法测定马来酸罗格列酮的血浆药物浓度; 以3P97软件计算磷酸罗格列酮药动学参数。结果与结论-马来酸罗格列酮在犬体内呈现1级吸收权重为1的一室模型规律; 其主要的药动学参数为 V (c) 约 0 4231 mg/kg/ (μg·ml-1), T1/2(ke)约107 6 min, CL约0 0027 mg·kg-1·min/ ( g·ml-1)。

Objective To determine the pharmacological parameters of rosiglitazone in dogs. Methods The concentration of rosiglitazone in dog plasma was determined by HPLC and the pharmacological parameters were calculated by Practical Pharmacokinetic Program Version 97(3P97) soft. Results and Conclusions The results showed that the pharmacological characteristics of rosiglitazone in dog were one order absorption and two apartments distribution. V(c) was about 0.4231 mg/kg/(μg· ml^(-1)),T (1/2(ke)) about 107.6 min, CL about 0.0027 mg·kg^(-1)·min/(μg·ml^(-1)).