长托宁与阿托品用于全身麻醉前用药的比较

Comparision of penehyclidine hydrochloride and atropine in preanesthetic medication of general anesthesia

目的比较长托宁与阿托品在全身麻醉前用药中的优缺点。方法108例全身麻醉病人随机分为两组,A组肌注长托宁0.5mg(n=54例);B组肌注阿托品0.5mg(n=54例),分别记录每组病人肌注药物前及30min后开始麻醉时的心率(PR)、镇静情况、气道分泌物情况及其不良反应。结果A组PR在肌注长托宁30min后与肌注前差异无显著性意义(P﹥0.05);B组变化具有显著性差异(P<0.05)。A组病人镇静效果(16例)、抑制病人气道分泌物情况明显好于B组(P<0.05);两组病人不良反应的差异无显著性意义(P﹥0.05)。结论长托宁对心率的影响弱于阿托品;长托宁可以起到一定的镇静作用;长托宁抗胆碱时效较阿托品更持续,能更有效控制全身麻醉期间气道分泌物。

Objective To compare penehyclidine hydrochloride(PH) with atropine and observe the merit, the shortcoming in preanesthetic medication of general anesthesia. Methods 108 patients for general anesthesia were divided into two groups randomly, group A used 0.5mg PH(n=54);group B used 0.5mg Atropine(n=54). Signed each patient's PR before intramuscling, at the beginning of anesthesia after 30 minutes; observed the effect of keeping patients sedate, the air passage's secretion of the patients and the adverse reaction. Results The patient's PR in group A didn't clearly change by intramuscling PH after 30 minutes(P﹥0.05).The sedate effect and controlling the air passage's secretion of the patients in group A were better than that in group B (P<0.05). There was not serious adverse reaction between two groups(P﹥0.05). Conclusion PH is weaker than Atropine in affecting PR;PH have a little sedate effect;The PH's effect of anticholinesterase is longer than Atropine's. PH can more effectively control the air passage's secretion of the patients during general anesthesia.