光子氧辐射自血回输疗法对高血压患者抗-oxLDL抗体及过氧化损伤的干预研究

Effects of UBIO on anti-oxLDL antibody and damage of peroxidation of the essential hypertensive patients

目的探讨抗-oxLDL抗体(抗oLAB)、过氧化损伤与高血压病(EH)的相关性及光子氧辐射自血回输疗法(UBIO)对其的干预作用。方法选择48例EH患者随机分成UBIO组及丹参组,用ELISA法、黄嘌呤氧化酶法、硫代巴比妥酸比色法测定EH患者治疗前后血中抗oLAB、超氧化物歧化酶(SOD)、丙二醛(MDA)水平,并与27例正常对照组进行对比分析。结果(1)EH患者血中抗oLAB、MDA水平较正常对照组明显增高,SOD水平明显降低,差异有显著性意义(P<0.001);(2)UBIO干预治疗后抗oLAB、MDA水平明显降低,SOD水平明显增高(P<0.05-0.01);丹参治疗后仅见MDA水平降低,SOD水平增高(P<0.001),抗oLAB降低不明显(P>0.05);两组治疗后相比,UBIO组在降低抗oLAB、MDA及辅助降血压方面疗效优于丹参组(P<0.05-0.001);3)直线相关分析示:EH组抗oLAB与SOD呈负相关关系(r=-0.3674、P<0.01),与MDA呈正相关关系(r-0.5037、P<0.001);SOD与MDA呈负相关关系(r=-0.6245、P<0.001)。结论EH患者存在LDL的氧化修饰及过氧化损伤,UBIO对其有较强的干预作用,且疗效优于丹参。

Objective To study the correlation between the anti-oxidized-low density lipoprotein(an-ti-oxLDL) antibody(anti-oLAB), the damage of peroxidation and essential hypertension (EH), and probe into the effects of ultraviolet blood irradiated and oxygenation(UBIO) on EH. Methods 48 EH patients were divided into 2 groups randomly:UBIO group and danshen group. The content of anti-oLAB, SOD and MDA in the blood of different patients were measured by ELISA, Xanthine oxidase (XOD) and thiobarbituric acid colorimotry . The results were compared with the control group contained 27 normal people. Results (1)The content of the anti-oLAB and MDA increased but the content of SOD decreased significantly(P<0. 001) in the EH group. (2) Post- treatment with UBIO, the content of anti-oLAB and MDA of EH patients decreased and the content of SOD increased obviously(P <0. 05-0. 01). The content of anti-oLAB in the danshen group, however, had no significant changes (P>0. 05), and the changes of MAD and SOD were similar to the UBIO group. These results indicated that UBIO had more effects than danshen on treating EH(P<0. 05-0. 001). (3)Correlation analysis suggested: It was obtained to the significant negative correlation (r=-0. 367 4,P<0. 01) between anti-oLAB and SOD and the significant positive correlation (r=-0. 503 7,P<0.001) between anti-oLAB and MDA. The relationship between SOD and MDA appeared negative correlation (r=0. 624 5,P<0. 001). Conclusion The pathogenesis of EH is related to modification and damage of oxidation, UBIO played more roles in intervention.