摘要
目的探讨新疆维吾尔族2型糖尿病(T2DM)患者自主神经病变与心率变异(HRV)及其他脏器受损的关系.方法选择确诊为T2DM的150例维吾尔族住院患者,其中单纯糖尿病(SDM)组72例,合并心血管疾病的糖尿病(DC)组78例,病程＜5年组54例,5～10年组51例,＞10年组45例.正常对照(NC)组为健康的维吾尔族人60名,全部进行24 h动态心电图及HRV分析.结果T2DM患者HRV均小于NC组(t'=6.5366～9.5677,P＜0.05),DC组的HRV较SDM组低(t=4.0791～8.9233,P＜0.05),病程＞5年的两组患者所有正常R-R间期的标准差值均低于病程＜5年组(t=7.5935～10.631,P＜0.05).结论HRV是早期判断维吾尔族T2DM患者自主神经病变最准确而又最敏感的方法,可能对是否合并心脏缺血性病变有提示作用.
Objective To study the relationship of autonomic nervous damages with heart rate variability (HRV) and cardirvascular diseases in T2DM of Uighur people. Methods 150 T2DM Uighur patients and 60 healthy Uighur controls were selected into the study. 150 T2DM patients were divided into 2 groups with and without cardiovascular diseases and into two courses of <5 and >5 years. Results HRV in T2DM group were lower than in the control group (P<0.05 ). In T2DM with cardiovascular diseases HRV were lower than in group without cardiovascular diseases. SDNN were lower in the group of >5 year than in the groups of <5 year (P<0.05 ). Conclusion Decrease in HRV is a sensitive clinical marker for detecting diabetic autonomic neuropathy early. It may be useful for evaluating the accompanying of cardiovascular diseases in T2DM Uighur patients.
