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维生素E对大鼠糖尿病肾病的防治作用及其机制 被引量:2

The effect of vitamin E on preventing and treating rat diabetic nephropathy and its mechanism
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摘要 DM鼠经维生素E治疗后,24 h尿白蛋白定量、肌酐清除率、肾脏肥大指数、二酰基甘油含量及胞膜蛋白激酶C(PKC)活性均低于糖尿病未治组。 Urinary protein excretion, creatinine clearance rate, kidney/body weight, total DAG contents and membrane PKC activity in the renal glomeruli were significantly improved in diabetic rats at the 2 or 24 weeks of vitamin E treatment than those without treatment. The GBM thickness was also ameliorated in the vitamin E treatment group.
出处 《中华糖尿病杂志(1006-6187)》 CSCD 北大核心 2005年第1期67-68,共2页
关键词 维生素E 糖尿病肾病 防治作用 大鼠 治疗后 肌酐清除率 二酰基甘油 肥大 治疗组 病理改变 Diabetic mellitus Kidney glomerulus Diglycerides Protein kinase C Vitamin E
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  • 1Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes, 1998,47:859-866.
  • 2Koya D, Lee IK, Ishii H, et al. Prevention of glomerular dysfunctions in diabetic rats by treatment of d-α-tocopherol. J Am Soc Nephrol, 1997,4: 426-435.
  • 3Preiss JE, Loomis CR, Bishop WR, et al. Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes,and ras- and sis-transformed normal rat kidney cells. J Biol Chem, 1986,261: 8597-8600.
  • 4Craven PA, DeRubertis FR. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. J Clin Invest, 1989,83:1667-1675.

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