心理性勃起功能障碍前扣带回氢质子波谱研究

Study on 1H MRS of the anterior cingulate cortex of psychogenic erectile dysfunction

目的 研究心理性勃起功能障碍(ED)患者前扣带回代谢的改变,探讨心理性ED可能存在的潜在病因和病理生理机制。方法 运用磁共振波谱(MRS)研究 18例心理性ED患者和 18例年龄匹配的健康志愿者双侧前扣带回的多体素氢质子(1H MRS)波谱特点,测定N 乙酰天门冬氨酸(NAA)、肌酸 (Cr)、胆碱 (Cho)代谢物浓度。结果 NAA在心理性ED组两侧前扣带回均低于正常对照组,差异有显著性(P<0. 05);两组两侧Cho,Cr均无明显差异。结论 前扣带回参与了心理性ED的病理生理过程;前扣带回的结构和 /或功能的异常可能是心理性ED潜在的病因之一。

Objective To study the changes of the anterior cingulate cortex metabolites with MRS, to provide the help in exploring possible underlying unrecongnised aetiological factor and pathophysiology machanicisms of the patients with psychogenic erectile dysfunction. Methods Eighteen cases with the psychogenic erectile dysfunction, and 18 normal matched subjects (the control subjects) were performed on a clinical 1.5 T MRI/MRS system. Proton multi voxel spectroscopy imaging ( 1H MRSI) was obtained from tow sides of the anterior cingulate cortex. The metabolites included N acetylaspartate (NAA), creatine and phosphocreatine (Cr), choline containing compounds (Cho). The value of the NAA, Cr, and Cho were calculated by integration of their peaks. Multivariate analysis of variance (MANOVA) was used to test both the value of NAA, Cho, Cr of the anterior cingulate cortex for group difference, with group as between subjects factor and side as within subjects factor. Results The NAA in patients was significant lower than that in the control subjects. There was no significant difference of the Cho and Cr between both groups. Conclusion The anterior cingulated cortex may participate in the pathophysiology of psychogenic ED. The abnormalities of the function and /or structure of the anterior cingulated cortex of the patients with psychogenic ED may be the one of the underlying anaetiological factors of psychogenic ED.