麝香酮的2种不同包合物及脂质体载体经皮扩散比较研究

Study of diffusion of muscone in different inclusion complexes and liposome through rat skin in vitro

目的:比较麝香酮(muscone)在β-环糊精、HP β 环糊精分子包合物中以及脂质体载体中的透皮扩散情况。方法:采用Franze扩散池,进行小鼠离体皮肤渗透扩散试验,比较其透皮扩散特征。结果:麝香酮HP-β-环糊精分子包合物以及脂质体后的经皮渗透速率明显大于麝香酮,麝香酮β-环糊精包合物则较低。结论:麝香酮HP-β-环糊精包合或脂质体化后能够促进麝香酮的经皮渗透。

Objective: To compare the penetrating rate of muscone in different inclusion complexes and liposome. Method: The transdermal effect of muscone in different inclusion complexes and liposome was studied comparatively on rat skin with 40%EtOH as the absorption solution and with an improved Franz diffuse cell. Result: Among the different inclusion complexes and liposome, the penetrating rate of muscone in the HP-β-cyclodextrin inclusion and the liposome were higher than muscone,and that of muscone in the β-cyclodextrin inclusion is the lowest. Conclosion: the HP-β-cyclodextrin inclusion and the liposome can hence the muscone transdermal speed.