生半夏、姜半夏对水貂呕吐作用的影响研究

Effect of Rhizoma Pinelliae on vomiting in minks

目的:研究半夏对水貂的致呕及止呕作用。方法:ig生半夏2 g·kg-1,观察对水貂的致呕作用;制备姜半夏醇提物、姜半夏水提物及姜半夏水煎剂,观察在 ip顺铂(7.5 mg·kg-1)、sc阿朴吗啡 (1.6 mg·kg-1)水貂呕吐模型的止呕作用;观察姜半夏水煎剂对水貂运动呕吐模型(100 r·min-1,1 h)的影响。结果:生半夏有致呕作用(P<0.01);姜半夏、胃复安、恩丹西酮对顺铂、阿朴吗啡致水貂呕吐均有抑制作用 (P<0.05)。结论:姜半夏在水貉呕吐模型中具有止呕作用,其机制与中枢抑制有关。

Objective: To study emetic and anti-emetic effects of Rhizoma pinelliae in minks. Method: The emetic effect of raw pinellia 2 g kg^(-1)(ig) was investigated. Three preparations of Rhizoma pinelliae (processed with ginger) were made by ethanol extraction, water extraction and water decoction respectively and their effects on emesis model induced by cisplatin (7.5 mg kg^(-1),ip) or apomorphine(1.6 mg kg^(-1), sc) were then studied; the effect of the decoction of ginger-grocessed Rhizoma pinelliae on rotation-induced emesis model in minks was also observed. Result: The emesis was induced by raw pinellia in minks(P<0.01); ginger-processed Rhizoma pinelliae, metoclopramide and ondansetron significantly inhibit the emesis induced by cisplatin and apomorphine(P<0.05). Conclusion:Ginger-processed Rhizoma pinelliae exhibits a anti-emetic effect in minks, which may be mediated by inhibiting the function of the vomiting center in central nervous system.