鹅不食草挥发油治疗过敏性鼻炎作用机理的研究

Histopathological study on allergic rhinitis treated with Centipeda minima

目的:探讨鹅不食草治疗过敏性鼻炎的作用机理。方法:运用豚草花粉过敏原建立豚鼠过敏性鼻炎的动物模型,通过提取鹅不食草的有效成分,对过敏性鼻炎进行治疗,观察豚鼠鼻黏膜组织形态学的动态病理变化。结果:过敏性鼻炎阳性对照组鼻黏膜上皮组织充血、水肿,炎性细胞浸润,可见大量中性粒细胞、嗜酸性粒细胞、淋巴细胞以及肥大细胞,鼻黏膜上皮细胞出现大量溶酶体、细胞器空泡化、细胞核变形,固有层结缔组织细胞结构紊乱,细胞器呈碎片状。而鹅不食草挥发油治疗组上述变化明显减轻至接近阴性对照组。结论:鹅不食草挥发油对过敏性鼻炎有明显治疗效果。

Objective: The aim of this study was to investigate the mechanisms of C. minima in the treatment of allergic rhinitis. Method: An allergic rhinitis animal model induced by ragweed pollen was established. After treatment with an active extract of C. minima, histopathological changes in the nasal mucosa of guinea pig were observed by transmission electron microscope. Result:In the allergeic rhinitis model group,there appear a large number of lysosomes in the nasal epithelium with organelles vacuolated and nucleus deformed. Cells in the proper lamina of connective tissue were disarranged with organelles damaged,and there was also infiltration of eosinophils and mast cells in the connective tissue. However,in the treatment group receiving C. minima extract, the pathological changes mentioned above were significantly decreased. Conclusion:C. minima is effective in treating allergeic rhinitis.