流行性出血热胃粘膜病变的进一步研究

A further study of gastric mucosa lesion in patients with hemorrhagic fever

研究目的进一步研究流行性出血热（EHF）胃粘膜病变的规律性。研究方法368例EHF患者中男212例，女156例。年龄10～72岁，其中儿童患者（10～12岁）75例，平均30.5岁。对照组100例中，男59例，女41例，年龄10～55岁，其中10～12岁老42例，平均30岁。采用OlympusGIF一K2型纤维胃镜，由专人操作，观察胃底、胃体、胃窦部，分别在以上各处钳取粘膜组织2～6块，HE染色镜检，对内统观察结果分级分度。对30例患者进行了13天至8个月的随访。结果293倒成人患者10O％异常．儿童患者62例异常（82.67％），总异常率为96.47％对照组100例中19异常（19.0％）两组比较有显著性差异（P＜0.01）。胃粘膜病变为具有特征性的急性／亚急性出血性胃炎，随着病情加，重而加重，随着病情改善而改善。小儿患者胃粘膜病变较成人患者为轻。结论胃粘膜病变是EHF全身病变的一部分。

Objective The aim is further study the regularity about gastric mucosa lesion of patients with hemorrhagic fever.Methods Using the gastriscopy and biopsy,the changs of gastric mucosa were investigated in368 EHF patients (male 212 cases, female 156 cases, age from 10~72 years old) and 100 cases of normal contoal (male 59 cases, feInale 41 cases, age from 10~55 years old). Olympe gastroscope was used and operated with sole duty. The gastric mucosa in fundus, antfum and copus were took and stained with hemotoxylin and cosin (H.E), and were compared with normal porson. The gastric mucosa lesion of 30 patientS were follwed up (from 13 days to 8 months).Results The abnomal rates of gastric mucosa were 96.47% (adult 100%, children 82.6%) in EHF patients, and compared with 19.0% in control group (P<0.01). The character istic changes of gastric mucosa in EFH patients were acute / subacute hemorrhagic gastritis.The pathological changes were worsened and improved in pace with severe and better of patients conditions correspondinglly. The lesion of gastric mucosa in EHF adult were se Jerer than children. Conclution The pathological lesion of gastric mucosa are a part of the whole body in EHF patients.