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脑源性神经营养因子在缺血性脑损伤中对神经细胞凋亡的作用及其信号传导途径

Effect of brain-derived neurotrophic factor on apoptosis of brain suffered from hypoxic-ischemic injury and its possible signal passway
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作者 俞丹 毛萌
机构地区 四川大学华西第二医院儿科
出处 《中国当代儿科杂志》 CAS CSCD 2005年第1期84-87,共4页 Chinese Journal of Contemporary Pediatrics
关键词 脑源性神经营养因子 缺血性脑损伤 神经细胞 细胞凋亡 信号传导 分子生物学
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献27

  • 1刘京升,孙正义,董晓丽.脑源性神经营养因子对大鼠坐骨神经损伤诱导神经元凋亡的作用[J].中华实验外科杂志,2002,19(2):130-131. 被引量：13
  • 2周晖,毛萌,刘卫平,李胜富,王华.脑源性神经营养因子对缺氧胚鼠脑皮质神经元的保护作用[J].华西医科大学学报,2002,33(4):573-576. 被引量：25
  • 3汤亚南,赵凤临.Caspase-3与围产期缺氧缺血性脑损伤[J].中国当代儿科杂志,2002,4(1):75-78. 被引量：10
  • 4Macmanus JP, Buchan AM, Hill IE, Rasquinha I, Preston E. Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain [J]. Neurosci Lett, 1993, 164(1-2): 89-92.
  • 5Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, et al. Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain [J]. Stroke, 2003, 34(1): 207-213.
  • 6Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, et al. Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation [J]. Proc Natl Acad Sci USA, 2002, 99(23): 15188-15193.
  • 7Davoli MA, Fourtounis J, Tam J, Xanthoudakis S, Nicholson D, Robertson GS, et al. Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat [J]. Neuroscience, 2002, 115(1): 125-136.
  • 8Gill R,Soriano M,Blomgren K,Hagberg H, Wybrecht R,Miss MT, et al. Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain [J]. J Cereb Blood Flow Metab, 2002, 22(4): 420-430.
  • 9Love S. Apoptosis and brain ischemia [J]. Prog Neuropsychopharmacol Biol Psychiatry, 2003, 27(2): 267-282.
  • 10Ishida A, Kawakami H, Yasuzumi F, Morishita R. Gene therapy for cerebral infarction (cerebral ischemia) [J]. No To Shinkei, 2002, 54(3): 213-219.

二级参考文献14

  • 1M. J Groves,T Christopherson,B Giometto,F Scaravilli. Axotomy-induced apoptosis in adult rat primary sensory neurons[J] 1997,Journal of Neurocytology(9):615～624
  • 2Renolleau S,Aggoun-Zouaoui D,Ben-Ari Y,et al.A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat: morphological changes indicative of apoptosis[].Stroke.1998
  • 3Nunez G,Benedict MA,Hu Y,et al.Caspases: the proteases of the apoptotic pathway[].Oncegene.1998
  • 4Nakajima W,Ishida A,Lange MS,et al.Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat[].The Journal of Neuroscience.2000
  • 5Cheng Y,Deshmukh M,D’Costa A,et al.Caspase inhibitor afford neuroprotection with delayed administration in a rat modal of neonatal hypoxic-ischemic brain injury[].The Journal of Clinical Investigation.1998
  • 6Vanderluit JL,Mcphall LT,Fermandes KJL,et al.Caspase-3 is activiated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents[].European Journal of Neuroscience.2000
  • 7Wang X,Karlsson JO,Zhu C,et al.Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia[].Biology of the Neonate.2001
  • 8Nath R,Scott M,Nadimpalli R,et al.Activation of apoptosislinked caspase(s) in NMDA-injured brains in neonatal rats[].Neurochemistry International.2000
  • 9Schulz JB,Weller M,Moskowitz MA.Caspases as treatment targets in stroke and neurodegenerative diseases[].Annals of Neurology.1999
  • 10Srinivasula SM,Fernandes-Alnemri T,Zangrilli J,et al.The Ced-3/interleukin 1βconverting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2αare substrates for the apoptotic mediator CPP32[].Journal of Biological Chemistry.1996

共引文献44

中国当代儿科杂志
2005年 第1期

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