连翘苷对营养性肥胖小鼠减肥作用的影响

Effect of Phillyrin on the Anti-obesity in Nutritive Obesity Mice

目的:研究连翘苷对营养性肥胖小鼠的减肥作用。方法:采用高脂饲料建立小鼠肥胖模型,以脂肪湿重,全视野内脂肪数目(HBF)、空肠绒毛表面积变化、Lee’s指数及血清总胆固醇和甘油三酯等指标,观察连翘苷的减肥作用。结果:连翘苷可以使肥胖小鼠脂肪湿重减轻(P<0 .01),脂肪系数变小(P<0. 05或P<0 .01),全视野内脂肪细胞数目增加(P<0 .01),脂肪细胞直径变小(P<0 .01),空肠绒毛表面积减小,Lee’s指数减小(P<0. 05),降低肥胖小鼠血清总胆固醇和甘油三酯水平。结论:连翘苷对营养性肥胖小鼠有一定的减肥作用。

Objective:To study on the anti-obesity effect of phillyrin in nutritive obesity mice.Method:The alimentary obesity model was established by hyperalimentation.The wet weight of fat,fat index,number of fat cells per unit visual field,Lee's index,jejunum microvillus area,serum triglyceride and cholesterol were selected to observe the anti-obesity effect of phillyrin.Result:Phillyrin could lower wet weight of fat (P<0.01),fat index(P<0.05 or P<0.01),diameter of fat cell and Lee's index (P<0.05),decrease the jejunum microvillus area,lower the level of serum triglyceride and cholesterol.Conclusion:Phillyrin has anti-obesity effect in nutritive obesity mice.