辛夷注射液窦腔灌注治疗家兔慢性上颌窦炎

The therapeutic effects of irrigating therapy with magnolia injection on chronic maxillary sinusitis experimentally induced among rabbits

目的建立家兔慢性上颌窦炎模型,观察自制辛夷注射液对慢性上颌窦炎的治疗效果。方法家兔28只,分为4组,其中实验组24只,再分为3组。在全麻下打开上颌窦前壁裂隙植入明胶海绵并注入金黄色葡萄球菌5周后制成慢性上颌窦炎模型。①空白组窦腔内灌注生理盐水2ml;②阳性对照组窦腔灌注庆大霉素2ml(8万U);③治疗组窦腔灌注辛夷注射液2ml。并于第3、5、7天分别以同样方法重复灌注。第10天处死动物做细菌培养和病理学检查。结果治疗组共有3个窦腔培养结果为阳性,对照组13个窦腔培养结果为阳性,空白组共14个窦腔分泌物有细菌生长。1、2、3组动物所有鼻窦黏膜均有炎症表现,但轻重程度不同。治疗组黏膜基本正常,对照组和空白组黏膜上皮排列不整齐,部分变性、坏死、脱落,有小溃疡形成,黏膜充血水肿明显并有炎细胞浸润。结论辛夷注射液窦腔内灌注对慢性上颌窦炎有很好的治疗作用。

Objective To investigate the therapeutic effects of irrigating therapy with magnolia injection (MNI)on chronic maxillary sinusitis experimentally induced among rabbits. Methods The animal model with chronic maxillary sinusitis was prepared by placing a piece of glutin sponge into the sinus cavity via the route of its front wall and injecting some quantity of Staphylococcus aureus into it. Then,the modeling animals were divided into 3 groups,each with 8rabbits. The animals in first group were irrigated into the sinus cavity with 2ml of NS as negativecontrols(NC) ,ones in the second group were irrigated into the cavity with gentamycin(80000U/ 2ml)as positive controls(PC) ,and those in the third group were irrigated into the cavity with 2ml of MNI(TG). All the animals were irrigated 4 times in total,once every other day. On the tenth day,all the animals were put into death for bacteria culturing of secretion from the sinus cavity and for histopathological assay of the sinus mucosa. Results Positive culturing was seen in 3 sinus cavities of TG,13 cavities of PG and 14 cavities of NC. On the other hand,all the sinus mucosa of three groups showed inflammatory reaction. However, the degree of inflammatory reaction was largely varied among these groups,with very mild inflammation in those of TG and severe inflammatory changes in those of either NC or PC. Conclusion MNI holds significant therapeutic effects on chronic sinusitis when used as local irrigating solution.