经典型卡波氏肉瘤16例血清IL-6、VEGF、TNF-α和IFN-γ的检测分析

Analysis to the Blood Serum Concentration of the IL-6、VEGF、TNF-α and IFN-γ in 16 Cases of Classic Kaposi's Sarcoma

采用ELISA(enzyme linkedimmunoadsordentassay)法检测16例新疆经典型卡波氏肉瘤(Kaposi'ssarcoma,KS)及64例正常对照的血清中IL 6、VEGF、TNF α和IFN γ血清浓度。探究了经典型卡波氏肉瘤发病机制与血清中白细胞介素(interleukin 6,IL 6)、血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)、肿瘤坏死因子(tumornecrosisfactor α,TNF α)、干扰素γ(interferon,IFN γ)紊乱之间的关系。研究结果表明:血清IL 6、VEGF和TNF α在KS病例组与对照组之间差异具有显著性(P值分别为0.040、0.002和0.043)。IFN γ在KS病例组与对照组之间差异无显著性,P值为0.067。这说明,血清IL 6、VEGF、TNF α的紊乱与经典型KS的发生存在一定的关系。

The paper discusses the relation between the pathogenesis of Classic Kaposi's Sarcoma(KS) and the disturbance of the Interleukin-6(IL-6),vascular endothelial growth factor(VEGF),tumor necrosis factor-α(TNF-α),Interferon-γ(IFN-γ) in blood serum. We used ELISA(Enzyme-linked immunoadsordent assay) to detect the blood serum concentration of the IL-6,VEGF,TNF-α and IFN-γ of 16 Classic Kaposi's Sarcoma and 64 controls in Xinjiang.The result showed that the blood serum concentration of IL-6,VEGF and TNF-α has significant differences between the KS patients and the normal controls.The pseparately equal to 0.040、0.002 and 0.043. IFN-γ has no significant difference. The pequals (0.067.)These data illustrated the the disturbance of the IL-6,VEGF and TNF-α has some relationship with Classic Kaposi's Sarcoma.