小诺米星在新生儿的药物动力学

Pharmacokinetics of micronomicin in neonates

本文报告２０例患儿（男性１２例，女性８例；日龄１５±ｓ８ｄ）应用小诺米星，Ａ组１０例以４ｍｇ／（ｋｇ·ｄ），Ｂ组１０例以５ｍｇ／（ｋｇ·ｄ），均ｂｉｄ，静脉滴注，观察其药物动力学与肾毒性。单剂０．５ｈ滴毕。结果：血药峰值分别为４．５与４．７μｇ／ｍＬ（Ｐ＞０．０５）。２组药物动力学参数（Ｖｄ，Ｃｌ，ＡＵＣ）与肾毒性参数（β２－ＭＧ，ＢＵＮ）差别均无显著意义（Ｐ＞０．０５）。提示该药用于新生儿，且剂量增至５ｍｇ／（ｋｇ·ｄ）于１ｗｋ内应用是安全的。

Micronomicin was given by iv infusions at the dosages of 4(group A n=10)and 5(group B n=10) mg/(kg·d),bid to 20 neonates(M 12,F8;age 15±8 d).Each dose was given in half an hour.The results showed that Cmax was 4.5 and 4.7 μg/mL(P>0.05),respectively,and the pharmacokinetic parameters(Vd,Cl,AUC)and the kidney toxicity(β2-MG,BUN)of the two groups were not much different.They indicate that micronomicin can be safely used in neonates, and within 1 wk when the usual dosage of micronomicin is increased to 5 mg/(kg·d).