2种剂量利福定在肺结核短程治疗中的疗效比较

Efficacies of two dosages of rifandin in intensive treatment of pulmonary tuberculosis

晨起空腹顿服利福定，治疗痰结核杆菌阳性患者２１８例。Ａ组１０７例（男性７６例，女性３１例；年龄３０±ｓ１１ａ），用量为４５０ｍｇ／ｄ；Ｂ组１１１例（男性８２例，女性２９例；年龄３２±１０ａ），用量为１５０－２２５ｍｇ／ｄ，并与Ｃ组用利福平的１０９例患者比较。３组疗程均为９ｍｏ。结果：Ａ组疗效明显优于Ｂ组，与Ｃ组相仿。不良反应Ａ组比Ｂ组多见，但与Ｃ组相似。

Two hundred and eighteen patients of active pulmonary tuberculosis with positive sputum cultivations were treated with rifandin qd,po,before breakfast in the morning.These patients were divided into 2 groups.Group A 107 patients(M76,F31,age 30± 11 a) received rifandin 450 mg/d.Group B 117 patients(M82,F29,age 32±10 a)were given rifandin 150-225 mg/d.Analysed these 2 groups and contrasted with another group(group C)treated by rifampicin reciprocally.All three groups patients'therapy course for 9 months duration. Results showed that the therapoutic effects of group A was better than group B and similar to group C. Whereas the adverse reactions of group A were more than those group B and also similar to those of group C.