奥美拉唑与雷尼替丁治疗消化性溃疡急性大出血的比较

Omeprazole vs ranitidine in treating peptic ulcer with acute massive bleeding

消化性溃疡急性大出血６４例，分为２组。奥美拉唑组３２例（男性２６例，女性６例，年龄４６±ｓ１７ａ），剂量４０ｍｇ，ｉｖ，ｑ１２ｈ，连用３ｄ。雷尼替丁组３２例（男性２５例，女性７例，年龄４７±１６ａ），剂量１００ｍｇ，加入５％葡萄糖溶液１００ｍＬ中，静脉滴注，ｑ１２ｈ，连用３－５ｄ。如出血停止转入抗消化性溃疡的常规治疗。２组比较，奥美拉唑止血效果明显，住院无数缩短，粪隐血转阴也快（Ｐ各＜０．０５，０．０１和０．０１）。

Sixty-four patients with peptic ulcer with acute massive bleeding were equally divided into two groups.The omeprazole group(M26,F6;age 46±s 17 a) received omeprazole 40 mg,iv,q12 h,for 3d.The ranitidine group(M 25,F 7;age 47±16 a) received ranitidine 100 mg in 5% glucose solution 100mL, iv gtt,q 12 h, for 3-5d.They all aceepted routine antipeptic ulcer therapy after bleeding stopped.Definitive hemostasis was achieved in all the former group,but failed in 6 patients in the latter group(P<0.05).The former group needed less days of hospitalization(P<0.01),and less days of turning stool occult blood tests to negative(P<0.01)in comparison with the latter group.