摘要
冠心病46例(男性30例,女性16例;年龄57±s11a),口服地奥心血康200mg,tid,治疗4-8wk。采用二维多普勒超声心动图测定左心室功能。治疗后每搏量(SV)、每分输出量(CO)及射血分数(EF)值均增加(P<0.01),舒张早期血流峰值速度(VE)舒张期最大充盈率(PFR)均升高(P<0.01),同时心率、血压均下降(P<0.01)。不良反应轻微。*P<0.01。4不良反应4例患者出现轻度胃肠道反应,经减量及对症治疗后症状缓解,未中断治疗。讨论本文治疗前46例患者全部有左室舒张功能不全,12例合并左室收缩功能不全,后者占26%,与文献[3]认为左室舒张功能不全出现在收缩功能损害之前相符。本文用地奥心血康治疗4-8wk结果显示全部患者左室舒张功能及泵血功能均有改善。10例心功能Ⅲ级者同时合并左室收缩功能异常,治疗2wk后停用地高辛及利尿剂,继续单用地奥心血康治疗6wk,收缩功能维持在正常低限,表明该药有改善泵血功能作用。我们还观察到停用地奥心血康后,患者心功能改善仍可维持4-6wk。患者心功能改善的机制,我们认为与下列因素有关:血压下降后使总外周阻力下降、减轻心脏收缩期负荷;心率减慢后使心肌氧耗?
Forty-six patients(M30,F16;age 57± s11 a) with coronary heart disease were treated with DI-ao-xin-xue-kang 200 mg po tid for 4-8 wk.Before and after treatment cardiac function were assessed by two-dimensional Doppler echocardiography.Results showed that the heart rate, systolic and diastolic blood pressure,mean artery pressure were all decreased (P< 0.01); left ventricular systolic function parameters(SV.CO and EF) were improved (P<0.01), left ventricular diastolic function parameters(peak velocity E.PFR and NPFR)were also improved (P<0.01) Adverse reactions were mild.
出处
《新药与临床》
CSCD
北大核心
1994年第2期90-92,共3页
关键词
地奥心血康
皂甙
冠状动脉疾病
Di-ao-xin-xue-kang
saponins
heart function tests
coronary disease