1Furchgott RF,Zawadzki JV.The obligatory role ofen-dothelial cells in the relaxaion of arterial smooth muscle by acetylcholine[J].Nature,1980,288:3732-3736.
2Ignarro LJ,Buga GM,Wood KS,et al.EndotheIium -derived relaxating factor from artery and vein is nitric oxide[J].Proc Natl Acid Sci USA,1987,84:92965-92969.
5Verrey F,Closs EI,Wagner CA,et,al.CAT and HATs:the SLC7 family of amino acid Transporters Pflugers[J].Arch,2004,447(5):532-542.
6Nicholson B,Sawamura T Masaki T,et al.Increased CAT3-mediated cationic amino acid transport funct-ionally compensates in CAT1 knockout cell lines[J].J Biol Chem,1998,273:14663-l4666.
7Graf P,Forstermann U,Closs EI.The transport acti-vity of the human cationic amino acid transporter hCAT-1 is downregulated by activation of protein kinase C[J].Br J Pharmacol,2001,132:1193-1200.
8Zharikov SI,Sigova AA,Chen S,et al.Cytoskeletal regulation of theL-arginine/NO pathway in pulmona-ry artery endothelial cells[J].Am J Physiol,2001,280:465-473.
9Closs EI.Expression,reguIation and function of car-rier proteins for cationic amino acids[J].Curr Opin Nephrol Hypertens,2002,11:99-107.
10Nicholson B,Manner CK,Kleeman J,et al.Sustai-ned nitric oxide production in macrophages requires the arginine transporter CAT2[J].J Biol Chem,2001,276:15881-15885.