摘要
目的 探讨诱导型环氧和酶 (COX -2 )抑制剂尼美舒利对慢性脑缺血损害的保护作用。方法 大鼠随机分为对照组、缺血组和治疗组 ,治疗组于术后 2 4h开始以尼美舒利 (6mg/kg)每日灌胃 ,连续 60d ,各组于 60d后做病理染色、GFAP免疫组化染色及脑组织内MDA和SOD含量的测定。结果 与对照组相比 ,缺血组GFAP阳性细胞明显增多 ;脑内的SOD含量下降 ,MDA含量增多。治疗组以上变化明显减轻 ,且有显著性差异。结论 COX -2抑制剂尼美舒利对慢性脑缺血损伤有脑保护作用。
Objective To investigate the neuroprotective effect of a cyclooxygenase-2 inhibitor nimesulide on brain damages after chronic cerebral hypoperfusion. Methds 48 SD rats were distributed into sham operation group, and nimesulide group randomly. The nimesulide group received a daily oral dose of 6mg/kg nimesulide from 24h after the operation to 60 days. Then observe the activation of astrocytes and MDA contents and SOD activities in brain tissues. Results There were obvious proliferation of astrocytes ,elevation of MDA and reduction of SOD in hypoperfusion group. In nimesulide group all the changes were reduced significantly. Conclusion The results confirms the ability of nimesulide to reduce chronic cerebral hypoperfusion brain damage.
