摘要
本文综述了阿尔茨海默病(Alzheimer's disease,AD)转基因小鼠模型近年来的研究进展,对各种转基因小鼠模型进行了系统的分类归纳,对不同模型的优缺点进行了讨论,并展望了其发展前景。
The recent advances in the studies of transgenicmouse models of Alzheimer s disease ( AD) are reviewed. Various single and multiple transgenic mouse models with well-characterized AD-like neuropathology that show some forms of cognitive impairment are described. In order to summary the models, they are classified by using transgenes. And the suitability, limitations of them and their contribution to an understanding of the pathophysiology of AD and related disorders are discussed. Furthermore, More suitable models are expected to clevelor.
出处
《中国临床神经科学》
2005年第1期98-101,共4页
Chinese Journal of Clinical Neurosciences
