哮喘患儿血浆神经肽A测定

Changes of plasma neurokinin A in asthmatic children

目的:观察哮喘患儿血浆神经肽A(NKA)含量的变化,探讨NKA与小儿哮喘的关系。方法:利用ELISA 法测定20例正常儿童、38例儿童哮喘发作期(其中重度发作20例,轻、中度发作18例)及26例哮喘缓解期患儿血 浆NKA的含量。结果:哮喘发作期患儿血浆NKA含量((326±148)ng·L-1)高于哮喘缓解组((84±39)ng· L-1)及正常对照组((51±30)ng·L-1),差异有统计学意义(P<0.05);后2组比较差异无统计学意义(P> 0.05)。重度哮喘发作患儿血浆NKA含量((359±160)ng·L-1)高于轻、中度哮喘发作患儿((208±113)ng· L-1)(P<0.01)。结论:NKA参与了哮喘发作的病理生理过程,可能是小儿哮喘发作的重要因素之一。

Aim: To investigate the changes of plasma neurokinin A (NKA) in asthmatic children and possible relationship between NKA and asthma. Methods: Plasma was collected from 38 cases of asthma during acute attack (including 20 cases of severe asthma, 18 cases of mild asthma ) , 26 cases of asthma during clinical remission, and 20 normal children. Plasma NKA was detected by ELISA. Results: The content of plasma NKA in cases of asthma during acute attack((326±148) ng·L -1)was significantly higher than that in cases of asthma during clinical remission ((84±39) ng·L -1)and the normal control group ((51±30) ng·L -1)(P<0.05); no significant difference in plasma NKA was found between the clinical remission group and the normal control group (P>0.05); the content of plasma NKA in children with severe asthma attack ((359±160) ng·L -1) was significantly higher than that in children with mild asthmatic attack ((208±113) ng·L -1)(P<0.01 ). Conclusion: NKA may play an important role in the pathogenesis of asthma in children.