腹膜血管形成对腹膜透析失超滤的影响

The relationship between peritoneal neoangiogenesis and ultrafiltration failure in peritoneal dialysis patients

目的 探讨腹膜透析失超滤的患病率及有关因素。方法 比较失超滤患者和非失超滤患者在透析龄、腹膜透析平衡试验 (PET)结果、腹膜炎、外周血白蛋白 (Alb)、高糖累积量及腹膜血管变化的差异。结果 失超滤患者的透析龄、腹膜通透性、高糖累积量及腹膜毛细血管的生成均高于非失超滤患者 ,但Alb相对较低 ;腹膜炎的患病率两组之间差异无显著性。结论 尿毒症环境、葡萄糖累积量的增多可能导致腹膜毛细血管的生成、腹膜的高转运 ,与腹膜透析的失超滤有关。

Objective To study the incidence and cause of ultrafiltration failure(UF) in peritoneal dialysis patients.Methods Respective analysis method was applied to investigate the relationship of the duration of peritoneal dialysis, peritonitis, serum albumin,high glucose accumulation(GA), peritoneal small molecular weight solute transport rate(PET),and peritoneal neoangiogenesis evaluated by detecting of the expression facter VIII by immunohistochemistry.Result The longer dialysis lasted,the higher rate of UF occured.GA and PET was higher,the increased expression of peritoneal neoangiogensis and serum albumin was lower in UF group compared with normal group.Peritonitis had no difference in two groups. Conclusion UF is mainly related with the duration of peritoneal dialysis and peritoneal neoangiogenesis.