米索前列醇用于晚期妊娠引产的效果研究

The Effect Misoprostol of Iabor Induction in Late Pregnancy

目的探讨米索前列醇对晚期妊娠引产的有效性和安全性。方法选择有引产指征、无引产及米索前列醇使用禁忌证的单胎、头位、胎膜完整的晚期妊娠妇女103例,随机分为A组(48例,米索前列醇)和B组(55例,催产素)。结果A组与B组引产成功率分别为77.08%、72.73%。首次用药至临产时间分别为6.18h、12.3h,首次用药至阴道分娩时间分别为369.23±235.90h、430.00±211.31min,有显著性差异(P<0.05)。分娩方式、新生儿体重,两组比较,差异均无显著性(P>0.05)。结论米索前列醇用于晚期妊娠引产有效而且安全。

Objective: To explore the efficacy and safety of misoprostol for labor induction in the third trimester of pregnancy. Methods: 103 term pregnant women with single pregnant?vertex present? intact membrane were selected in study group. All cases in study group indications for labor induction, without contra-indication of labor induction and misoprostol. The 103 women were randomly assigned A(misoprosstol) and B(oxytocine) groups. Misoprostol was placed in the posterior vaginal fornix every 4 to 6 hours .The maximum dose in 24 hours is 200 μg. Misoprostol was not given after either spontaneous rupture of membrane or beginning of active labor. Result: The sucesess rate of induction labor was groups 77.08%, 72.73% in group A and B, respectively. The average duration from administration of misoprostol to start of labor in two groups was 6.18 and 12.3 hours, respectively; the average duration from start of misoprostol use to vaginal delivery was 369.23±235.90 minutes and 430.00±211.31 minutes (p<0.05), respectively. The incidence of vaginal delivery had no statistics significant difference between two groups (P> 0.05). Conclusion: misoprostol is an efficient and safe dosage for labor induction in term pregnancy.