尿γ-谷氨酰基转移酶测定在鉴别泌尿系统感染中的价值

The value of γ-glutamyl transpeptidase in the differentiation of urinary system infection

目的 通过检测泌尿系统感染患者尿γ 谷氨酰基转移酶(GGT)水平,探讨检测尿GGT在泌尿系统感 染中的鉴别价值。方法 检测泌尿系统感染者的尿GGT及尿肌酐(Cr)水平,并用U/(g·Cr)表示酶活性单位。 通过受试者工作特征曲线(ROC)特性分析尿GGT在泌尿系统感染鉴别肾脏炎症时的临界值。结果 (1)肾脏 炎症组尿GGT水平显著高于对照组(P<0.01),下尿路感染患者尿GGT水平与对照组相比差异无显著性(P> 0.05);(2)ROC曲线特性分析显示,以75.0U/(g·Cr)为鉴别限时,特异性、阳性预测值和阴性预测值均最高, 能较好的区分肾脏炎症和下尿路感染,但敏感性和准确度均较低。以69.0U/(g·Cr)为鉴别限时,特异性、阳 性预测值和阴性预测值均较高,准确度最高,可以较好的筛选肾脏炎症患者。结论 检测泌尿系统感染患者尿 GGT水平,对肾脏炎症和下尿路感染的定位鉴别诊断有一定的价值。

Objective To explore the differential diagnostie value of γ-glutamyl transpeptidase(GGT) of urinary system infection by measurement of the level of urine GGT. Methods We detected the levels of GGT and creatinine (Cr), and expressed enzymatic activity by U/(g·Cr). Results were shown by receiver operator characteristic(ROC) curve for differentiation the urinary system infection from inflammation of kidney. Results (1) The level of GGT was significantly higher inrenal inflammation group than the control groups(P<0.01). But no significant difference was found between the urethral infection group and control groups(P>0.05); (2) Analysis of ROC curve showed that specificity, positive and negative prediction data were all high in 75.0 U/(g·Cr) and 69.0 U/(g·Cr). The renal inflammation and urethr infection could be diefferentiated in 75.0 U/(g·Cr) and 69.0 U/(g·Cr). Howerer, sensitivity and accuracy were lower in 75.0 U/(g·Cr), accuracy was the highest in 69.0 U/(g·Cr), 69.0 U/(g·Cr) was the better value for differentiation of renal inflammation. Conclusions GGT level measurement is valuable for the differential diagnosis of renal inflamemation and urethral infection.