早产危险因素meta分析

Meta-analysis on risk factors Of preterm birth

目的综合分析中国早产发生的危险因素.方法采用meta分析对国内1994～2003年发表的有关早产危险因素的文献进行汇总、归纳和定量综合分析.结果前置胎盘、产前出血、胎膜早破、多胎、臀位、妊高症、流产史、产前检查的合并OR值及其95%C1分别为7.8781(5.0103-12.3876)、5.4065(3.009-8.8552)、4.4165(3.2983-5.9133)、4.3601(2.6414-7.1973)、2.7070(1.8331～3.9972)、2.0432(1.3512-3.0895)、1.1651(0.7518～1.8057)、0.2946(0.2269-0.3824).结论前置胎盘、产前出血、胎膜早破、多胎、臀位、妊高症为早产的危险因素,流产史与早产的的关系尚不确定,产前检查为早产的保护因素.

Aim Our Purpose was to evaluate risk factor related to preterm birth in China.Methods Meta-analysis was used to evaluate the data extracted from 1994-2003 published papers on the risk factors of preterm birth in china.Results The pooled odds ratios(OR) for placenta previa,antepartum haemorrhage,preterm rupture of membranes,multiple pregnancy,breech presentation,hypertension of pregnancy,history of abortion,antenatal attendance were 7.8781(5.0103～12.3876),5.4065 ( 3.009～8.8552 ) ,4.4165 ( 3.2983～5.9133 ) ,4.3601 ( 2.6414～7.1973 ) ,2.7070 ( 1.8331～3.9972 ) ,2.0432 ( 1.3512～3.0895 ) ,1.1651 ( 0.7518～1.8057 ) ,0.2946 (0.2269～0.3824),respectively.Conclusion placenta previa, antepartum haemorrhage,preterm rupture of membranes,multiple pregnancy,breech presentation and hypertension of pregnancy can increase the risk of preterm birth,but the effect of history Ofabortion should be studied further,the antenatal attendance isprobably protective factor.