矽肺患者血清透明质酸及Ⅳ型胶原蛋白检测分析

Analysis of Serum Hyaluronic Acid and type IV collagen Levels of Silicosis

目的 研究血清透明质酸(HA)及Ⅳ型胶原蛋白 (CoIV)与矽肺病情之间的关系,探讨新的矽肺病病情监测方法。方法 用放免法测定 149例矽肺患者血清HA及CoIV含量,以同厂的 89例不接触矽尘工人作为对照。结果 Ⅲ期矽肺病人组血清HA水平为 272. 71±204. 65ng/ml,显著高于对照组 172. 31±120.18(P<0. 05); 148例矽肺患者血清CoIV平均浓度为 48. 94±277. 74ng/ml,与对照组相比有显著差异(P<0.001)。结论 血清HA、CoIV检测可作为矽肺患者病情监测的参考指标。

Objective To study the relationship between serum Hyaluronic Acid ( HA ), type IV collagen ( CoIV) levels and silicosis. Methods Levels of HA and CoIV were measured in 149 silicosis and 87 workers without silicosis in the same factory by using radio-immunoassay. Results The mean level of HA in stage III silicosis was 272.71ng/ml, which was much higher than that in control group 172.3ng/ml ( P <0.005). Conclusions The level of serum HA and CoIV may be as an index to reflect the silicosis condition.