锰作业人员行为功能调查

Survey on Neuro-behavioral Functions among Workers Exposed to Manganese

目的 了解锰(Mn)对人体的神经系统的损害,探索行为毒理学在职业流行病学研究中的实际应用价值,为进一步做好劳动保护工作提供依据。方法 采用WAIS成人智力量表中的成套行为指标及WHO推荐的“神经行为核心测验组合(MCTB)”,系统地对从事Mn作业人员进行测试,并设立对照组。结果 神经系统症状分数接触组比对照组高(P<0.01);接触组和对照组语言总分和操作总分两组均有显著性差异(P<0. 05);WHO核心行为功能测验 7个分测验的标准分两组之间大部分有显著性差异(P<0. 05);核心行为与专业工龄之间存在明显的负相关(P<0. 05);尿Mn与语言总分之间也存在明显负相关 (P<0. 01)。结论 长期低浓度的Mn接触对人体神经系统有明显的损害。

Objective To explore neurosystem damage of occupational population exposed to manganese. Methods Two exam-methods, WAIS ( Wechsler Adult Intelligence Scale ) and WHO's NCTB ( Neurobehavioral Core Test Battery ), were used to examine adult intelligence competence. Workers engaged in manganese working were designated as exposure group, while un-exposed administrative staff as control one. Results The results showed that average scores of neurosystem symptoms in exposure group were significantly higher than ones in the control (P<0.01) .There were distinct (statistical ) differences between the exposed and control ones in total scores of language and total ones of operation (P<0.05) .There were also significant differences between the exposed and control ones in the standaard scores of most of seven sub-tests of WHO.NCTB (P<0.05).There was a negative correlation between average level of scores of NCTB and the length of exposure service ( P<0.05 ). There was also a negative one between urine-Mn concentration and the total scores of language. (P<0.05). Conclusions It is evident that neurosystem damage to body is induced by occupational exposure in low-concentration manganese environment for a long time.