肠易激综合征患者血清IL-1β、IL-10及皮质醇变化的研究

Changes of Serum Interleukin-1β,Interleukin-10 and Cortisol in Patients with Irritable Bowel Syndrome

目的 探讨肠易激综合征 (IBS)患者血清白介素 (IL)和皮质醇 (CO)浓度变化及它们在IBS中的可能作用和临床意义。方法 随机抽取来源于门诊和住院IBS患者和健康志愿者血清 ,采用放射免疫法测量血清IL和CO浓度。结果 感染后IBS组IL -1β较对照组显著升高 (P <0 .0 1) ,非感染后组也高于对照组 ,但无统计学意义。非感染后IBS组IL- 10较感染后组和对照组均显著升高 (P <0 .0 1) ,感染后组和对照组无差异。感染后组和非感染后组CO均较对照组显著升高 (P <0 .0 5和P <0 .0 1)。结论 炎症因子和应激可能参与IBS发病。

Objective To investigate the changes of ser um interleukin(IL) and cortisol(CO) in patients with irritable bowel syndrome(IBS) and to study their possible role and clincal significance.Method The serum levels of interleukin and cortisol were measured by radioimmunoassa y in 20 controls and 36 patients with IBS randomly selected from outpatients and inpatients.Results A significant increase of IL-1β was found in IBS with infection groups compared to non-infection and control groups(P <0.01).IL-1β increased in IBS of non-infection group compared to the contro ls,but there was no statistics significance.IL-10 in IBS with non-infection gr oup markedly increased compared to that in infection group and controls(P<0. 01).There was no difference between infection group and control group(P>0.05 ).CO in IBS with infection and non-infection groups markedly increased compared to the controls(P<0.05?or?P<0.01).Conclusions Inflam mation agents and stress may participate in the incidence of IBS.