期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

急性冠脉综合征患者血浆脑钠素变化及其临床意义的研究进展 被引量：2

Research Progress on Change of Brain Natriuretic Peptide and Its Clinical Significance in Patients with Acute Coronary Syndrome
下载PDF
导出
摘要 心肌缺血损伤是血浆脑钠素 (BNP)释放的重要触发因素之一。急性冠脉综合征 (ACS)患者血浆BNP和氮端前体BNP(NT -proBNP)水平升高是患者危险分层的重要生物标志物 ,独立于传统的临床症状及其他生化指标如肌钙蛋白和C反应蛋白 (CRP)。血浆BNP和NT -proBNP水平越高 ,患者的心力衰竭的程度越重 ,病死率越高。 Cardiac ischemia is an important trigger for the rel ea se of B-type natriuretic peptide (BNP).High levels of BNP and N-terminal pro- BNP (NT-proBNP) are important biomarkers for risk stratification in patients wi th acute coronary syndromes,which are independent to traditional clinical variab les and other biochemical markers such as troponins and C-reactive protein.The higher the levels of BNP and NT-proBNP are,the more severe the patients with h eart failure are,and the higher the mortality are.
作者 王爱萍
机构地区 泰山医学院
出处 《现代诊断与治疗》 CAS 2005年第2期107-109,共3页 Modern Diagnosis and Treatment
关键词 患者 血浆脑钠素 急性冠脉综合征 NT-PROBNP 临床意义 触发因素 研究进展 前体 水平 生物标志物 BNP Acute coronary syndromes Risk-stratification
分类号 R541 [医药卫生—心血管疾病] R543.3 [医药卫生—心血管疾病]
  • 相关文献

参考文献15

  • 1Marumoto K,Hamada M,Hiwada K.Increased secretion of atrial and brain natriuretic peptides during acute myocardial ischemia induced by dynamic exercise in patients with angina pectoris[J].Clin Sci(Colch),1995,88:551-556.
  • 2Sabatine MS,Morrow DA,de Lemos JA,et al.Elevation of B-type natriuretic peptide in the setting of myocardial ischemia (abstract)[J].Circulation,2001,104(SuplⅡ):485.
  • 3Tateishi J,Masutani M,Ohyanagi M,et al.Transient increase in plasma brain(B-type)natriuretic peptide after percutaneous transluminal coronary angioplasty[J]. Clin Cardiol,2000,23:776-780.
  • 4Toth M,Vuorinen KH,Vuolteenaho O,et al.Hypoxia stimulates release of ANP and BNP from perfused rat ventricular myocardium[J].Am J Physiol,1994,266:1572-1580.
  • 5Hama N,Itoh H,Shirakami G,et al.Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction[J].Circulation,1995,92:1558-1564.
  • 6Morita E,Yasue H,Yoshimura M,et al.Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction[J].Circulation,1993,88:82-91.
  • 7Horio T,Shimada K,Kohno M,et al.Serial changes in artial and brain natriuretic peptides in patients with acute myocardial infarction treated with early coronary angioplasty[].Am Heart J,1993,126:293-299.
  • 8Arakawa N,Nakamura M,Aoki H,et al.Relationship between plasma level of brain natriuretic peptide and myocardial infarct size[].Cardiology,1994,85:334-340.
  • 9Omland T,Bonarjee VV,Lie RT,et al.Neurohumoral measurements as indicators of long-term prognosis after acute myocardial infarction[J].Am J Cardiol,1995,76:230-235.
  • 10Talwar S,Squire IB,Downie PF,et al.Profile of plasma N-terminal pro-BNP following acute myocardial infarction.Correlation with left ventricular systolic dysfunction[J].Eur Heart J,2000,21:1514-1521.

同被引文献28

  • 1苗锋.急性冠状动脉综合征患者C反应蛋白变化的临床意义[J].山东医药,2004,44(22):44-45. 被引量：16
  • 2关德明,佟滨,焦秀华.急性冠脉综合征的病理学机制[J].哈尔滨医科大学学报,2005,39(1):101-103. 被引量：4
  • 3Cowie MR, Jourdain P, Maisel A, et al. Clinical applications of B-type natriuretic peptide (BNP) testing[J]. Eur Heart J,2003,24(19) : 1710-1718.
  • 4Yano Y, Katsuki A, Cabazza EC, et al, Plasma brain natriuretic peptide levels in normotensive noninsulin- dependent diabetic patients with microalbuminuria [ J]. J Clin Endocrinol Metab, 1999,84 (7) : 2353- 2356.
  • 5Liu C, Agn~s G, Corcuff JB, peptide in type 2 diabetes: renal failure and food [ J ]. (3) :752. et al. B-type natriuretic the influence of chronic Diabetes Care, 2005,28.
  • 6Tamow L,Hildebrandt P, Hansen BV, et al. Plasma N-terminal pro-brain natriuretic peptide as an independent predictor of mortality in diabetic nephropathy [ J ]. Diabetologia, 2005,48 ( 1 ) : 149- 155.
  • 7Tschope C, Kasner M, Westermann D, et al. The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: correlation with echocardiographic and invasive measurements [ J ]. Eur Heart J, 2005,26 (21) :2277-2284.
  • 8Heintzen MP, HeidlandU, Strauer BE. Management of patients with acute coronary syndrome:should we rely on cardiac marker? [J ]. J Interven Cardiol, 2000,13: 447 ～ 452
  • 9Adams JE Brd, Abendschein DR, Jaffe AS. Biochemical markers of myocardial injury: is MB creative kinase the choice for the 1990s? [J].Circulation, 1993,88 (2): 750 ～ 763
  • 10Christenson RH , Duh SH, Sanhai WR, et al. Characteristics of an albumin Cobalt binding test for assessment of acute coronary Syndrome patients: a multicenter Study[J]. Clin Chem, 2001,47: 464 ～ 470

引证文献2

二级引证文献1

现代诊断与治疗
2005年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部