摘要
本文用动脉插管直接测压的方法，研究了六甲氧苄嗪（ＨＭＺ）对麻醉大鼠正常血压的影响。结果表明，ＨＭＺ能降低血压，以降低舒张压和平均压为主，且能部份对抗去甲肾上腺素的升压作用，同时与异丙肾上腺素合用时似有协同作用。初步认为ＨＭＺ的降压效应与α受体和β受体无明显关系，可能与抑制Ｃａ２＋通道有关。
We studied the action of hexametazidine(HMZ) on normal blood pressure in anesthetized rats.The results indicated that HMZ could decrease blood pressure and total peripheral resistance;in addition,it attenuated the hypertensive effect of noradrenaline and was cooperative action with isoetharine in reducing blood pressure.These findings indicated that HMZ was neither a α-adrenoceptor blocking agent nor a β-adrenoceptor exciting agent,suggesting that calcium channel blocking mechanism may be involved in action of HMZ.
关键词
六甲氧苄嗪
三甲氧苄嗪
降压药
药理学
hexametazidine
trimetazidine
blood pressure determination
rats
