星形胶质细胞瘤MRI形态与伽玛刀疗效关系的初步研究

Primary study on relationship between MRI characteristics and outcome after Gamma Knife radiosurgery for astrocytomas

目的探讨星形胶质细胞瘤的MRI形态特征与伽玛刀治疗效果的关系。方法回顾43例星形胶质细胞瘤病人的MRI特征和伽玛刀治疗结果。根据肿瘤的边界和强化效应特性,将肿瘤分为3型。以肿瘤缩小为有效判定指标。采用卡方检验,确定MR形态与伽玛刀治疗疗效的关系。结果20 例(46.5%)有效。其中Ⅰ型18例,13例(72.2%)有效;Ⅱ型15例,5例(33.3%)有效;Ⅲ型10例,2例(20.0%)有效。Ⅰ型病人的有效率较Ⅱ、Ⅲ型病人高,差别有统计学意义;而Ⅱ型与Ⅲ型之间无显著性差异。结论MRI形态可作为星形胶质细胞伽玛刀治疗预后的预测指标。

Objective To explore the relationship between MRI characteristics and outcome after Gamma Knife radiosurgery for astrocytomas. Methods The MRI characteristics and outcome after gamma knife radiosurgery for 43 patients with astrocytomas were reviewed. According to the representation of the edge and contrast enhancement features under the MRI, the astrocytomas were categorized into three types. The effective treatment was determined by astrocytoma shrinkage. The relationship between MRI characteristics and outcome after Gamma Knife radiosurgery was determined by χ2 test. Results Of 43 patients, 20 (46.5%) were treated effectively, including 13 (72.2%) of 18 in type I group, 5 (33.3%) of 15 in type Ⅱ group, and 2 (20.0%) of 10 in type Ⅲ group. χ2 test revealed that the effectiveness rate was significantly higher in type I group than in typeⅡ and Ⅲ groups, but was not significantly different between typeⅡ and type Ⅲgroups. Conclusion MRI characteristics can be regarded as the prognosis indication for astrocytomas after Gamma Knife radiosurgery.