4Chen M, Lee A, Hazell S. Immunisation against gastric helicobacter infection in a mouse/Helicobacter felis model. Lancet, 1992, 339:1120-1121.
5Mohammadi M, Czinn S, Redline R, Nedrud J. Helicobacter-specific cell-mediated immune responses display a predominant Thl phenotype and promote a delayedtype hypersensitivity response in the stomachs of mice. J Immunol, 1996, 156: 4729-4738.
6Mohammadi M, Nedrud J, Redline R, Lycke N, Czinn SJ.Murine CD4- T-cell response to Helicobacter infection:TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology, 1997, 113: 1848-1857.
7Ermak TH, Giannasca PJ, Nichols R, Myers GA, Nedrud J, Weltzin R, Lee CK, Kleanthous H, Monath TP. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class Ⅱ-restricted responses. J Exp Med, 1998, 188: 2277-2288.
8Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R. Helicobacter pylori virulence and genetic geography. Science, 1999, 284: 1328-1333.
9Michetti P, Corthesy-Theulaz I, Davin C, Haas R, Vaney AC, Heitz M, Bille J, Kraehenbuhl JP, Saraga E, Blum AL. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology, 1994, 107: 1002-1011.
10Suerbaum S, Thiberge JM, Kansau I, Ferrero RL,Labigne A. Helicobacter pylori hspA-hspB heat-shock gene cluster:, nucleotide sequence, expression, putative function and immunogenicity. Mol Microbiol, 1994, 14:959-974.
2Kleanthous H, Lee CK, Monath TP. Vaccine development against infection with Helicobacter pyloH. Br Med Bull, 1998,54: 229-241.
3Michetti P, Corthesy-Theulaz I, Davin C, et al. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology, 1994,107 : 1002-1011.
4Gomez-Duarge OG, Lucas B, Yah ZX, et al. Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B. Vaccine. 1998.16:460-471.
5Angelakopoulos H, Hohmann E. Pilot study of phoP. phoQ-deleted Salmonella enterica serovar typhimurium expressing Helicobacter pylori urease in adult volunteers. Infect Immun,2000,68 :2135-2141.