海马CA3区习得性LTP的进一步探讨

FURTHER STUDY ON THE LEARNING-DEPENDENT LONG-TERM POTENTIATION OF SYNAPTIC EFFICACY IN THE HIPPOCAMPAL CA3 REGION

分辨学习中大鼠ＰＰ－ＣＡ３突触效应有习得性ＬＴＰ产生，进一步观察到ＭＦ－ＣＡ３及Ｃｏｍｍ－ＣＡ３也同步地产生习得性ＬＴＰ，表明几种输入突触都产生习得性ＬＴＰ，而ＭＦ－ＣＡ３突触效应增强的程度则较Ｃｏｍｍ－ＣＡ３的为大（Ｐ＜０．０１）。海马ＣＡ３注入印防己毒素能易化ＰＰ－ＣＡ３突触习得性ＬＴＰ的产生，工作发现一侧海马ＣＡ３注印防己毒素，易化对侧ＭＦ－ＣＡ３突触习得性ＬＴＰ的产生，表明两侧海马ＣＡ３区在其习得性ＬＴＰ的形成上是相互协同的。

Previous work demonstrated that there was learning-dependent long-term potentiation (LDLTP)of synaptic efficacy at the PP-CA3 synapses of rats during learning.In the present study it was further observed that LDLTP happened synchronously at MF-CA3 and Comm-CA3 synapses in learning,but the potentiation degree of MF-CA3 synapse was much larger than that of Comm-CA3 synapse(P<0.01). previous work showed again that the injection of picrotoxin, GABA receptor antagonist, facilitated the production of LDLTP at PP-CA3 synapse during training, In this study, it was found that the injection of picrotoxin into the ipsilateral CA3 area could facilitate the production of LDLTP at contralateral MF-CA3 synapse and correspondingly the behavioral response.These results demonstrated that LDLTP can be induced at the synapses of several inputs in hippocampal CA3 during learn ing and both lateral CA3 areas coordinate each other for the induction of LDLTP.