脑出血早期应用β-七叶皂甙钠治疗的临床观察

Clinical Observation of β-Aescine on the Earlier Period of Cerebral Hemorrhage

目的 观察脑出血早期应用 β -七叶皂甙钠治疗的临床疗效。方法 采用前瞻性随机对照方法分为治疗组和对照组 ,治疗组在对照组治疗的基础上应用β -七叶皂甙钠 2 0mg加生理盐水 2 5 0mL静脉输注 ,每天 1次 ,连用 2 1d。结果 治疗组和对照组总有效率分别为 83 .82 %和5 7.5 8% (P <0 .0 1)。发病第 14天 ,治疗组血肿有所吸收 ,周围有轻微低密度区 ;对照组血肿吸收不明显 ,周围水肿明显。发病第2 8天 ,治疗组大部分病人血肿完全吸收 ,水肿带明显缩小 ,有些甚至未见水肿 ;对照组部分病人血肿完全吸收 ,大部分血肿周围水肿明显。结论 β -七叶皂甙钠有良好的改善微循环作用 ,对血肿周边缺血区有着重要意义 。

Objective To observe the clinical efficacy in the patients with acute cerebral hemorrhage. Methods Using prospective random contrast methods to divide them into treatment group and control group. The patients in treatment group, on the basis of control group, were treated by β-Aescine 20 mg added in 250ml normal saline intravenous drip once a day for 21 days.Results The total effective rate of treatment group and control group was respectively 83.82% and 57.58%(P<0.01). On the 14th day, the hematoma in treatment group was partly absorbed, but in control group the absorption was not obvious; in treatment group the peripheral edema zone was smaller than that in control group. On the 28th day, the hematoma of most patients in treatment group and some of in control group was absorbed completely, the edema zone in treatment decreased obviously or even disappeared, but the peripheral edema was still clear in bulk of control group. Conclusion β-Aescine has a satisfactory effect on microcirculation ameliorating. It plays an important role in peripheral ischemia region of the hematoma and has obvious curative effect on acute cerebral hemorrhage.