通窍健脑胶囊对大鼠脑缺血再灌注损伤后SOD、MDA及线粒体酶的影响被引量：10

Effect of Tongqiaojiannao Capsule on SOD/MDA and Mitochondrion Enzymes in Rats after Cerebral Ischemia Reperfusion Injury

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摘要目的　研究通窍健脑胶囊对实验性大鼠脑缺血再灌注损伤的保护作用。方法　Wis tar大鼠 3 6只 ,用结扎大鼠双侧颈总动脉不完全脑缺血 45min再灌注 90min模型 ,观察脑组织超氧化物歧化酶(SOD )、丙二醛 (MDA )含量、脑组织线粒体酶活性。结果　通窍健脑胶囊可明显升高SOD的含量 ,减少MDA的产生 ,增强线粒体酶的活性。结论　通窍健脑胶囊对脑缺血再灌注有显著的保护作用 ,其机制与抗自由基、抑制脂质过氧化反应。 Objective To study the protection of tongqiaojiannao capsule on experimental cerebral ischemia/reperfusion damage in rats.Methods An acute experimental incomplete cerebral ischemia Wistar rats model induced by ligating bilateral common carotid arteries for 45 minutes, and then reperfusion 90 minutes. Detect the levels of SOD and MDA and the activity of mitochondrial enzyme. Results Tongqiaojiannao capsule can obviously raise the level of SOD ,decrease MDA production , increase the activity of mitochondrial enzyme. Conclusion Tongqiaojiannao capsule possesses strong protection, which has relation with anti-free radical ,inhibiting lipid peroxidatic reaction, preventing mitochondria damage.

作者王锐李光来成学恭

机构地区北京市隆福医院山西医科大学第二医院

出处《中西医结合心脑血管病杂志》 2005年第3期234-236,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

关键词通窍健脑胶囊脑缺血再灌注 SOD MDA 线粒体酶 tongqiaojiannao capsule cerebral ischemia reperfusion SOD MDA mitochondrion enzymes

分类号 R277.7 [医药卫生—中医学]

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