长效二氢奎尼丁、普罗帕酮、美托洛尔对心室晚电位影响的临床研究

A Clinical Study on Influence of Long-Effect Dihydroquinidine,Propafenone and Metoprolol on the Ventricular Late Potentials

通过短期观察信号平均心电图（ＳＡ－ＥＣＧ）的重复性及比较心室晚电位（ＶＬＰ）阳性患者服药前后ＳＡ－ＥＣＧ指标变化，以了解长效二氢奎尼丁（ｓéｒéｃｏｒ）、普罗帕酮、美托洛尔对ＶＬＰ阳性患者ＳＡ－ＥＣＧ指标的影响，及是否具有逆转ＶＬＰ的作用，结果表明：（１）ＳＡ－ＥＣＧ各定量指标的重复性良好，ＶＬＰ阳性组自然转阴率仅为７．７％。（２）ｓｅｒｅｃｏｒ不能逆转ＶＬＰ，而具有选择性延长ＱＲＳ终末部４０μＶ的低振幅信号持续时间（ＬＡＳ）的作用。（３）普罗帕酮不能逆转ＶＬＰ，仅延长滤波后ＱＲＳ－时限（ＱＲＳ－Ｄ）。（４）美托洛尔显著逆转ＶＬＰ，使ＱＲＳ－Ｄ、ＬＡＳ缩短，综合导联滤波的ＱＲＳ终末４０ｍｓ处综合向量电压（ＲＭＳ_（４０））增加。讨论了三种抗心律失常药物对ＶＬＰ影响的不同效应。

The study was designed to determine the reproducibility of signal-averaged ECG(SA-ECG)indexes and the effects of long-effect dihydroquinidine(sérécor),propafenone and metoprolol on ventricular late potential(VLP)in short period.The results showed:(1)The reproducibility of the quantitative indexes of SA-ECG was good.natural VLP negative turn rate only was7.7%.(2)Long-effect dihydroquinidine had a selective effect on LAS,didn't influence on VLP negative turn rate.(3)Propafenone prolonged the QRS-D but didn't LAS.(4)VLP could been turn into negative by oral metoprolol. Metoprolol increased RMS40 and reduced QRS-D and LAS.The report has discussed the different influence of antiarrhythmic drugs on VLP.