冷凝消融室性心动过速中两种动物模型的比较研究

Comparative Studies of Cryoablation on Two Kind of Models of Ventricular Tachycardia

本研究比较了冷凝消融实验性室性心动过速（ＶＴ）中两种动物模型的特点及各自的局限性。结果表明：用心肌梗塞模型诱发ＶＴ适用于研究心肌梗塞后ＶＴ的产生机理、病理生理、血液动力学变化，评价药物疗效及观察预后等。而乌头碱局部心肌注射所用剂量小，诱发ＶＴ的时间短、诱发率高、持续时间长，是研究非药物治疗心律失常如电灼、冷凝、激光和化学消融等理想的ＶＴ模型。

The model of ventricular tachycardia(VT)induced by electric stimulation on myocardial infarction(MI)model was compared with the model of VT by aconitine. The results suggested that the former was suitable for studies of productive mechanism,pathopysiology.hemodynamics on VT after acute MI.evaluation of therapeutic effect of drug on VT as well as investigation of prognosis of VT.The latter was an ideal model for studies of nonpharmacotherapy of arrhythmias such as fulguration,cryoablation,laser ablation and chemical ablation for the amount of caonitine used in inducing VT each time was smaller,the successful rate of inducing VT was higher,the time spent in inducing VT was shorter and the duration of sustained VT was longer.