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儿童链球菌感染相关性自身免疫性神经精神障碍 被引量：1

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection
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摘要 强迫性障碍和抽搐性运动障碍是儿童期常见的神经精神障碍 ,其病因未明 ,二者可能具有相同的病因 ,即遗传和环境因素共同作用的结果。近年来链球菌感染后的自身免疫被认为是一个可能的环境引发因素 ,并提出了儿童链球菌感染相关性自身免疫性神经精神障碍的诊断。支持免疫性发病机制学说的证据包括在该类患儿中抗链球菌抗体及抗基底节抗体水平升高 ,B细胞抗原D8/17的存在 ,MRI研究中示基底节体积增大 ,以及应用免疫抑制剂治疗有效。对该类疾病目前已有明确的诊断标准和推荐的临床建议。
作者 马学梅 赵亚茹
机构地区 中国医科大学第二临床学院发育儿科
出处 《国外医学（儿科学分册）》 2005年第2期77-79,共3页 Foreign Medical Sciences（Section of Pediatrics)
关键词 链球菌感染 自身免疫疾病 强迫障碍 抽搐性运动障碍
分类号 R749.94 [医药卫生—神经病学与精神病学]
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参考文献23

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同被引文献21

  • 1周同甫.儿童A组链球菌感染的若干问题[J].实用医院临床杂志,2005,2(3):9-11. 被引量：3
  • 2曾仲,徐朝义,邓茜,张海涛,高励.与感染相关的儿童神经精神障碍[J].中国综合临床,2006,22(1):90-92. 被引量：1
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  • 5Murphy TK, Kurlan R, Leekman J. The immunobiology of to- urette's disorder, pediatric autoimmune neuropsyehiatric disor- ders associated with Streptococcus, and related disorders: a way forward [J]. J Child Adolesc Psyehopharmacol,2010,20(4): 317-331.
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  • 10Martino D, Defazio G, Giovannoni G. The PANDAS subgroup of tic disorders and childhood-onset obsessive - compulsive disor- der[J]. J Psychosom Res,2009,67(6):547-557.

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国外医学（儿科学分册）
2005年 第2期

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