广东沿海地区正常人群骨密度pDEXA测量正常值调查结果

Normal values of bone mineral density measured with pDEXA in people of Guangdong in China

目的 通过对使用DTX 2 0 0骨密度仪进行前臂尺桡骨骨密度人群调查资料的统计分析 ,获得广东沿海地区本地人群的骨密度 (BMD)正常值。并对资料的年龄组分布特点进行分析。方法 采用美国OsteometerMediTech公司的DTX 2 0 0骨密度仪 ,对广东沿海地区的本地籍人群 (男性 2 71人 ,女性2 75人 )进行前臂尺桡骨远段的BMD检查 ,对检查对象的一般信息 :身高、体重、生活习惯、饮食习惯、既往病史、女性月经史及生育哺乳史等进行详细记录。对测量的骨矿含量 (BMC)和面平均BMD按年龄组进行平均值和标准差的计算 ,根据 2 0～ 39年龄组计算男女骨峰值。结果 ①男性前臂远段骨峰值 :BMC =3. 96 0± 0 . 5 6 9,BMD =0 . 5 5 5± 0 . 0 6 0 ;女性为BMC =2 . 92 4± 0 . 35 9,BMD =0 . 4 72± 0. 0 39。男女BMD均在 30～ 39岁组达到高峰 ,但BMC达到峰值的年龄组均为 4 0～ 4 9。②各年龄组均值显示 :女性 15～ 19岁组BMD达到峰值的 91% ,而男性只达到 77% ;女性 6 0～ 6 9岁组BMD降到峰值的 72 % ,而男性降到 87% ;2 0岁以前 ,男女BMD差别较小 ;在达到峰值的年龄组 ,男女BMD差别较大 ,而BMC更为明显。③男性BMD峰值的标准差约为均值的 10 .8% ,女性约为 8 3% ;若按骨峰值降低两个标准差作为骨质疏松的判断标准 。

Objective The normal values of bone mineral content(BMC) and bone mineral density(BMD) measured with pDEXA in people of Guangdong in China were obtained and statistically analysed. Methods The measurements were conducted with DTX bone densitometer. The subjects were people residing in coastal region of Guangdong province, including 271 men and 275 women. The BMC and BMD of radius and ulna were measured. The general data, height, weight, habit of living and diet, case history, history of menstruation, pregnancy, maternity and lactation were recorded. The mean values and standard deviations(SD) of the data of measurement were calculated by age groups. The bone peak values(BPV) was calculated in age group of 20-39. Results ① The BPV of radius and ulna in men were 3.960±0.569 for BMC, and 0.555±0.060 for BMD;those in women were 2.924±0.359 for BMC, and 0.472±0.039 for BMD. In men and women,The age groups of the peak values weres 30-39 for BMD, but 40-49 for BMC. ② According to the mean values of age groups, the BMD in the age group of 15-19 reached 91% of the BPV in women, but only 77% in men. In the age group of 60-69, the BMD dropped to 72% of BPV in women, but only 87% in men. Before the age of 20, the difference of BMD between men and women was slight, but became greater in the age group of peak values. ③ The SD/mean values of the BPV of BMD were 10.8% in men and 8.3% in women. According to the criterion that BPV minus 2 SD(≈BPV-BPV×20%) is taken for diagnosis of osteoporosis, the positive rate was about 80% in women of age 60-69; in the criterion changes to BPV-BPV×25%, the positive rate was about 63%, but if the criterion changes to BMC-BMC×25%, the positive rate reduced to about 27%. Conclusions ① It is stable and reasonable to obtain the BPV from age group of 20-39. ② The bone grow more early and quickly in women before age of 20 than in men of that age. The BMD drops more early and quickly in old women than in old men. ③ According to the positive rate of osteoporosis in women aged 60-69, it is reasonable to use the BMD of BPV-BPV×25% as the diagnotic criterion of opteoporosis. ④ Due to interference of the geometric size of bone, BMC is not a suitable parameter for clinical diagnosis of osteoporosis.