高同型半胱氨酸血症与缺血性脑卒中关系

Association between Hyperhomocysteinemia and Ischemic Stroke

目的 分析高同型半胱氨酸 (Hcy)血症与缺血性脑卒中的关系。方法 应用高压液相色谱法(HPLC)对 35例缺血性脑卒中组患者和 35例对照组中的健康体检者进行血浆Hcy测定。结果 缺血性脑卒中患者的平均血浆Hcy(18. 9±6. 8)μmol/L高于对照组(11. 4±4. 1)μmol/L,且具有显著性差异(P<0. 001)。结论 高同型半胱氨酸血症是缺血性脑卒中的独立危险因子,应该给予重视及治疗。

Objective The role of hyperhomocysteinemia(Hcy) as independent risk factor for ischemic stroke needs to be confirmed. To assess the association between risk of ischemic stroke and increasing values of plasma homocysteine. Methods The concentration of plasma(Hcy) in 35 patients with ischemic stroke and 35 healthy controls was measured by using high performance liquid chromatography(HPLC). Results The concentration of Hcy (18.9±6.8)μmol/L in study group was found to be significantly higher than that (11.4±4.1)μmol/L of normal controls(P< 0.001).Coclusion Hyperhomocysteinemia is an independent risk factor for ischemic stroke.