心内直视手术患者血浆S100β蛋白变化的意义

Significance of Serum S100β Protein during Pericardio Pulomonary Bypass Period in Cardiac Surgical Patients

目的 探讨血浆S100β蛋白在体外循环中和术后脑损伤评价中的意义。方法 体外循环下心内直视手术病人 40例,在体外循环中和结束后不同时间点采血测定血浆S100β浓度,并观测病人术后精神神经系统并发症。结果 体外循环可引起病人血浆S100β蛋白明显升高,水平最高的 3例术后均出现明显的精神神经系统症状,术后 24h无精神神经并发症者血浆S100β蛋白恢复到术前水平。结论 体外循环引起的血浆S100β蛋白水平变化对体外循环术后脑损伤的评价具有重要意义。

Objective To discuss the values of plasma S100β protein in evaluating the cerebral injuries during the peri-CPB period.Methods 40 cardiac surigcal patients with CPB were studied,blood samples were taken during the peri-CPB period and to measure plasma level of S100β protein and observed neuropsychological complication after operation.Results CPB aroused that S100 β protein increased signifcantly,and decreased the baseline value on 24 hours after CPB.3 patients with the highest level appeared neuropsychological morbidity.Conclusion S100β protein has significant change during peri-CPB period.Its level has very great significance in evaluating cerebral injuries.