MxEP与EP方案治疗晚期非小细胞肺癌的疗效比较

Comparison of MxEP and EP regimen in treatment for advanced non-small cell lung cancer

目的 :观察和比较MxEP与EP方案治疗晚期非小细胞肺癌 (NSCLC)的疗效和不良反应。方法 :30例Ⅲ～Ⅳ期NSCLC采用MxEP方案 [足叶乙甙 (VP16 ) 75mg/m2 ,第 1～ 5天 ;顺铂 (DDP) 30mg/m2 ,第 1～ 3天 ;米托蒽醌 (MxT) 10mg ,第 2天 ]联合化疗。 2 7例Ⅲ～Ⅳ期NSCLC采用EP方案 (VP16 75mg/m2 ,第 1～ 5天 ;DDP30mg/m2 ,第 1～ 3天 )联合化疗。结果 :MxEP组CR和PR共 17例 ,有效率 5 6 .7% ,中位缓解期 6个月 ,中位生存期 13个月 ;EP组CR和PR共 11例 ,有效率33.3% ,中位缓解期 3个月 ,中位生存期 8个月 ,两组疗效差异有显著性 (Ρ <0 .0 5 )。主要的毒副反应为食欲减退、恶心呕吐、白细胞、血小板减少 ,患者均可耐受。结论

Objective:To observe and compare the effect and major adverse reaction of the two chemotherapy regimens(MxEP and EP) in treatment of advanced non-small cell lung cancer (NSCLC).Methods:Thirty cases of advanced NSCLC (stage Ⅲ-Ⅳ) patients were treated with MxEP regimen(MxT 10 mg,d 2;VP16 75 mg/m 2,d 1-5;DDP 30 mg/m 2,d 1-3),and the other 27 cases were treated with EP regimen (VP 16 75 mg/m 2,d 1-5;DDP 30 mg/m 2,d 1-3).Results:In the MxEP group,the overall response rate was 56.7 %( CP+PR=17),the medium response time was 6 months and the medium survival time was 13 months.In the EP group,the overall response rate was 33.3 %( CP+PR=11),the medium response time and medium survival time were 3 and 8 months.The major side effects were anorexia,nausea,vomiting,leucopenia and thrombocytopenia,which were tolerable for most cases.Conclusions:The MxEP regimen is a good choice for treatment of NSCLC.