摘要
目的:研究环氧合酶 2(COX 2)在子宫内膜异位症(内异症)在位子宫内膜组织和异位子宫内膜组织 中的表达及意义。方法:采用免疫组织化学方法检测30例卵巢内异症在位内膜、10例卵巢巧克力囊肿壁异位内膜 及27例正常子宫内膜中COX 2的分布和表达。结果:COX 2在3组子宫内膜腺上皮细胞和间质细胞中均可见表 达。COX 2在正常对照组内膜和卵巢内异症组在位内膜腺上皮细胞中的表达均是分泌期高于增生期(P<0.05), 而在间质细胞中的表达分泌期与增生期比较无统计学差异(P>0.05)。COX 2在卵巢内异症组在位和异位内膜中 的表达均高于对照组(P<0.05),而内异症患者在位和异位内膜中COX 2的表达则无统计学意义(P>0.05)。结 论:COX 2在卵巢内异症在位和异位内膜中表达增高,可能与卵巢内异症的病理异常有关。
Objective To investigate the expression of cyclooxygense-2 (COX-2) in eutopic and ectopic endometrium in ovarian endometriosis. Methods Thirty patients with ovrian endometriosis, 10 with ovarian chocolate cysts and 27 normal controls were enrolled to determine the expression of COX-2 immunohistochemically in eutopic or ectopic endometrium or healthy endometrial tissues. Results The immunoreactivities of COX-2 were found in epithelial cells and stromal cells in eutopic endometrium. The expression of COX-2 in the epithelial cells in the secretory phase was higher than that in the proliferative phase in the control group and ovarian endometriosis group (P<0.05). But the expression of COX-2 in stromal cells in the control group and ovarian endometriosis group showed no cyclic changes throughout the menstrual cycle (P>0.05). The expression of COX-2 in eutopic and ectopic endometrium in the ovarian endometriosis group was higher than that in the control group (P<0.05), but we did not find significant difference between the eutopic and ectopic endometrium in the ovarian endometriosis group (P>0.05). Conclusion The increased COX-2 expression in eutopic and ectopic endometrium in ovarian endometriosis may be related to its pathology.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2005年第1期92-95,共4页
Journal of Central South University ：Medical Science
基金
湖南省卫生厅医学科研基金(Y02 034)
