国产膨体聚四氟乙烯在整形美容外科中的应用

Application of China-made expanded polytetrafluoroethylene in plastic and aesthetic surgery

目的评估国产膨体聚四氟乙烯(ePTFE)在整形美容外科中的临床效果. 方法采用国产ePTFE,以进口ePTFE作为对照,根据不同需要分别置于额部、颞部、鼻部、颏部、鼻基底及上颌部,矫正面部软组织缺损及凹陷畸形,比较2组术后伤口愈合、不良反应及临床效果. 结果试验组16例18个部位,术后随访6～9个月,其中1例(鼻部)因埋置过浅、过于接近切口继发感染而取出;1例(颏部)伤口愈合不良,假体外露,经换药后术后2周Ⅱ期愈合;其余病例临床观察未见明显过敏反应、炎症反应及排异反应,外形保持良好,满意率94.4%(17/18).对照组10例12个部位,术后随访6～9个月,1例(鼻部)假体外露取出,其余病例未出现异常情况,满意率为91.7%(11/12).2组在伤口愈合情况(χ2=1.109,P=0.574)、不良反应(P=1.000)和临床疗效(P=1.000)等方面均无显著性差异. 结论国产ePTFE具有良好的组织相容性,适合充填软组织,可作为安全而廉价的替代产品.

Objective To evaluate the clinical efficacy of China-made expanded polytetrafluoroethylene (ePTFE) in the treatment of facial defects and hollow deformities on the face. Methods Facial augmentation was performed in different sites as the forehead, temple, nose, chin, nosal base and maxilla, respectively, to correct the facial defects and hollow deformities, by using either China-made ePTFE (Experimental Group) or imported ePTFE (Control Group). Postoperative parameters between the two groups were compared. Results The Experimental Group included 16 patients (18 sites), in whom the postoperative follow-up was conducted for 6~9 months. In this group, a secondary infection (in the nose) occurred in 1 patient because the implant was placed too superficially and too close proximity to the incision, and the implant was removed out. Delayed healing of the incision (in the chin) with uncovered implant was found in 1 patient, who was cured by the change of dressing. In the rest of the patients, no obvious allergic, inflammatory or rejection reaction was seen and a good cosmetic result was achieved. The satisfactory rate of this group was 94.4%(17/18). The Control Group included 10 patients (20 sites). The implant was found bared and then removed in 1 patient (in the nose). The satisfactory rate of this group was 91.7%(11/12). There were no statistical differences between the two groups in the wound healing ( χ 2 =1 109, P =0 574), the adverse reaction ( P =1 000), and the clinical efficacy ( P =1 000). Conclusions China-made ePTFE gives histocompatibility as good as imported one. It is suitable for filling the soft tissue and can be used as a safe and economical alternative.