低分子肝素联合阿司匹林对急性冠状动脉综合征患者血小板功能的影响

Effects of low molecular heparin and aspirin on platelet activation in patients with acute coronary syndrome.

目的探讨低分子肝素和阿司匹林联用对急性冠状动脉综合征患者血小板活化及纤溶功能的影响。方法采用酶联免疫双抗体夹心法检测低分子肝素和阿司匹林联合治疗急性冠状动脉综合征患者血小板表面α颗粒膜蛋白(GMP140)、血管性假血友病因子(vWF)、组织纤溶酶原激活剂(tPA)、纤溶酶原激活剂抑制物1(PAI1)及D二聚体的含量变化。结果33例急性冠状动脉综合征患者经7d治疗后血浆GMP140、D二聚体和PAI1浓度显著降低(P<0.01),血浆vWF亦显著降低(P<0.05)。结论低分子肝素和阿司匹林联用可降低急性冠状动脉综合征患者血小板激活、内皮受损及血液高凝状态。

Objective To investigate the changes of platelet activation and fibrinolysis before and after using low molecular heparin and aspirin in the patients with acute coronary syndrome (ACS).Methods The plasma concentration of platelet alpha-granule membrane glycoprotein-140(GMP-140),plasminogen activator inhibitor-1(PAI-1),tissue-type plasminogen activator (t-PA),von Willebrand factor(vWF) and D-dimer(D-D) were measured by ELISA before and after of treatment of low molecular heparin and aspirin in 33 cases with ACS.Results In 7 days after using low molecular heparin and aspirin treatment in 33 patients with ACS,GMP-140,D-D,PAI-1 and vWF were decreased significantly.Conclusion The results indicated that the activation of platelet and fibrinolysis activity was decreased after treatment with low molecular heparin and aspirin in the patients with ACS.