再生障碍性贫血患者细胞遗传学异常的相关因素分析

Analysis of the related factors of aplastic anemia patients to follow the cytogenetic abnormalities treated with immunosuppressive theropy.

目的探讨再生障碍性贫血(再障)患者应用免疫抑制剂及细胞因子治疗后出现细胞遗传学异常的可能相关因素。方法治疗组76例再障患者应用免疫抑制剂及细胞因子治疗前后均行骨髓细胞染色体核型检查。对照组68例再障患者给予康力龙等常规治疗,并在相同时间行骨髓细胞染色体核型检查。结果治疗组有9例出现染色体异常核型,其中5例转化为骨髓增生异常综合征,4例仅有染色体异常核型而无转化;对照组无一例出现细胞遗传学异常。结论长期应用免疫抑制剂及细胞因子治疗可能会引起再障患者出现细胞遗传学异常,甚至演化为骨髓增生异常综合征。

Objective To explore the possible related factor of developing of cytogenetic abnormalities of bone marrow cells from the aplastic anemia patients treated with immunosuppressive theropy(IST) and granulocyte colony-stimulating factor(G-CSF).Methods Chromosome karyotypes of bone marrow cells were measured in 76 aplastic anemia patients of treatment group before and after treated with IST and G-CSF.Chromosome karyotypes of bone marrow cells of 68 control were assayed by same method,respectively.Results Nine in 76 patients of treatment group were observed cytogenetic abnormalities,Five in 9 patients developed myelodysplastic syndrom(MDS),Four in 9 patients were only observed cytogenetic abnormalities.None of 68 control were observed cytogenetic abnormalities.Conclusion Cytogenetic abnormalities may be observed in aplastic anemia patients after long term IST and administration of G-CSF.