PSA、FPSA与ECT骨显像对前列腺癌骨转移的诊断价值

The Diagnosis Value of PSA/FPSA and ECT in Prostate Cancer Bone Metasasis

目的:为探讨前列腺特异性抗原(PSA和FPSA)与单光子发射型电子计算机断层(ECT)骨显像对前列腺癌骨转移的诊断价值。方法:对62例前列腺癌患者的PSA和FPSA的检测结果及ECT骨显像进行回顾性分析。结果:前列腺癌骨转移组和非骨转移组PSA和FPSA的均值差异均有显著性(P<0.01);62例前列腺癌中骨显像阳性47例,42例确诊为骨转移,转移率为67.8%,其中有1例PSA<10μg/L,2例PSA在10μg/L～20μg/L之间,4例PSA在20μg/L～50μg/L,35例PSA在50μg/L以上(占83%)。结论:PSA<10μg/L的前列腺癌患者发生骨转移的可能性小;PSA>50μg/L的患者发生的骨转移的可能性大。骨显像与血清PSA和FPSA浓度联合检测对于前列腺癌骨转移的临床诊断具有重要的指导意义。

Objective to evaluate the diagnosis value of PSA/FPSA and ECT bone scan in prostate cancer(Pca) Bone metasasis(BM).Methods sixty-two cases of prostate cancer were reviewed about the PSA/FPSA and ECT bone scan.Results The value of PSA and FPSA between BM and Non-BM groups had significant difference(P<0.001). BM occurred in 42 cases,the morbidity of BM was 67.8 %,one case PSA<10 μg/L,two cases PSA 10 μg/L^20 μg/L, four cases PSA 20 μg/L^50 μg/L, thirty-five cases PSA>50 μg/L(about 83 %).Conclusion PSA<10 μg/L,the morbidty of BM is rare; while PSA>50 μg/L,BM is in high suspect.The combined detection of the bone scan and the serum PSA/FPSA levels would play am important role in clinic diagnosis with Pca BM.