卵巢黏液性腺癌的免疫组化研究

An immunohistochemical study of primary and secondary ovarian mucinous adenocarcinoma

目的 探讨卵巢原发性黏液性腺癌与转移性黏液性腺癌的组织学和免疫组织化学特点。方法 选择已确诊的卵巢原 发性黏液性腺癌24例,转移性黏液性腺癌16例(其中胃5例,阑尾5例,结直肠6例)。复习所有病理切片,并进行CK7和CK20免疫 组化染色。结果 24例卵巢原发性黏液性腺癌CK7均呈弥漫强阳性表达,而CK20仅3例有局灶阳性表达。16例转移性黏液性腺 癌中,6例结直肠转移性腺癌和5例阑尾转移性腺癌的CK20均呈弥漫强阳性表达,而CK7则只有1例呈局灶阳性表达;5例胃转移 性黏液性腺癌CK7均呈阳性,4例CK20阳性。结论 卵巢原发性黏液性腺癌与转移性胃肠道黏液性腺癌具有明显不同的免疫组化 特征,CK7和CK20在二者的鉴别诊断中具有重要价值。

Objective To study the histological and immunohistochemical features of primary and metastatic ovarian mucinous adenocarcinoma. Methods 24 cases of primary ovarian mucinous adenocarcinoma and 16 cases of metastatic mucinous adenocarcinoma (5 gastric, 5 appendix, 6 colorectal) with definite diagnosis were included in this study. All the tissue sections with either HE staining or immunohistochemical staining with CK7 and CK20 monoclonal antibodies were studied. Results All the 24 primary mucinous adenocarcinoma were positive for CK7 and only 3 cases showed focal positive for CK20. Among the 16 secondary mucinous adenocarcinoma, 6 colorectal and 5 appendiceal metastatic adenocarcinoma were positive for CK20 and only one metastasis showed focal positiveness for CK7. The five gastric metastatic mucinous adenocarcinoma showed strong CK7 expression and four of them were CK20 positive. Conclusions The primary and secondary mucinous adenocarcinoma of the ovary had different immunohistochemical features. CK7 and CK20 were valuable markers in the differentiation of these two entities.